Carl-Henrik Heldin Selected Research

Platelet-Derived Growth Factor

1/2022	The protein kinase LKB1 promotes self-renewal and blocks invasiveness in glioblastoma.
12/2009	Combined anti-angiogenic therapy targeting PDGF and VEGF receptors lowers the interstitial fluid pressure in a murine experimental carcinoma.
7/2009	Prognostic significance of stromal platelet-derived growth factor beta-receptor expression in human breast cancer.
1/2007	An activating mutation in the PDGF receptor-beta causes abnormal morphology in the mouse placenta.
1/2007	PDGF receptors as targets in tumor treatment.
4/2004	Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.
3/2004	Oral imatinib mesylate (STI571/gleevec) improves the efficacy of local intravascular vascular endothelial growth factor-C gene transfer in reducing neointimal growth in hypercholesterolemic rabbits.
10/2002	Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

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Carl-Henrik Heldin Research Topics

Disease

66	Neoplasms (Cancer) 01/2022 - 08/2002
11	Breast Neoplasms (Breast Cancer) 01/2022 - 03/2005
11	Prostatic Neoplasms (Prostate Cancer) 09/2020 - 02/2003
9	Carcinoma (Carcinomatosis) 01/2018 - 03/2002
7	Neoplasm Metastasis (Metastasis) 01/2022 - 07/2006
5	Carcinogenesis 01/2022 - 01/2010
3	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2018
3	Glioma (Gliomas) 01/2022 - 09/2006
3	Hyperplasia 01/2022 - 03/2004
3	Experimental Melanoma 01/2020 - 04/2004
3	Inflammation (Inflammations) 10/2019 - 08/2002
3	Triple Negative Breast Neoplasms 10/2018 - 04/2017
3	Melanoma (Melanoma, Malignant) 02/2011 - 12/2007
2	Lung Neoplasms (Lung Cancer) 03/2021 - 01/2016
2	Pulmonary Arterial Hypertension 01/2020 - 11/2019
2	Hypoxia (Hypoxemia) 01/2020 - 02/2010
2	Virus Diseases (Viral Diseases) 01/2020 - 10/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 03/2008
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2007 - 10/2004
2	Atherosclerosis 12/2006 - 01/2004
2	Neointima 12/2006 - 03/2004
1	Osteosarcoma (Osteogenic Sarcoma) 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 11/2021
1	Endometrial Neoplasms (Endometrial Cancer) 07/2021
1	Circulating Neoplastic Cells 01/2020
1	Hereditary Hemorrhagic Telangiectasia 01/2020
1	type 2 Hemochromatosis 01/2020
1	Lewis Lung Carcinoma 01/2020
1	Vascular Diseases (Vascular Disease) 11/2019
1	Fever (Fevers) 10/2019
1	Dengue (Dengue Fever) 10/2019
1	Severe Dengue 10/2019
1	Infections 10/2019
1	Liver Neoplasms (Liver Cancer) 05/2019
1	Hepatocellular Carcinoma (Hepatoma) 05/2019

Drug/Important Bio-Agent (IBA)

15	Transforming Growth Factor beta (TGF-beta)IBA 03/2021 - 03/2002
14	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022 - 07/2012
14	Proteins (Proteins, Gene)FDA Link 10/2021 - 08/2002
11	Transcription Factors (Transcription Factor)IBA 11/2019 - 07/2006
11	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 12/2018 - 10/2002
10	Becaplermin (PDGF-BB)FDA Link 01/2022 - 04/2004
10	Phosphotransferases (Kinase)IBA 01/2022 - 12/2006
8	Platelet-Derived Growth FactorIBA 01/2022 - 10/2002
7	Messenger RNA (mRNA)IBA 01/2022 - 08/2002
7	Imatinib Mesylate (Gleevec)FDA Link 01/2020 - 09/2003
6	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2021 - 08/2002
6	TNF Receptor-Associated Factor 6 (TRAF6)IBA 03/2021 - 02/2009
6	Pharmaceutical PreparationsIBA 01/2020 - 05/2003
5	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 01/2015 - 10/2002
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2007
4	UbiquitinIBA 03/2021 - 06/2005
4	Ligases (Synthetase)IBA 03/2021 - 06/2005
4	CytokinesIBA 07/2017 - 10/2008
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 10/2007
3	Epidermal Growth Factor (EGF)IBA 01/2020 - 01/2016
3	Hyaluronic Acid (Hyaluronan)IBA 01/2020 - 01/2019
3	ErbB Receptors (EGF Receptor)IBA 01/2020 - 03/2011
3	Protein Isoforms (Isoforms)IBA 01/2020 - 05/2012
3	p38 Mitogen-Activated Protein KinasesIBA 01/2014 - 02/2003
2	Protein Kinases (Protein Kinase)IBA 01/2022 - 01/2016
2	NestinIBA 01/2022 - 10/2021
2	TNF Receptor-Associated Factor 4IBA 03/2021 - 09/2013
2	EndoglinIBA 01/2020 - 02/2010
2	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 01/2020 - 01/2015
2	CollagenIBA 11/2019 - 01/2017
2	Tyrosine Kinase InhibitorsIBA 12/2018 - 02/2011
2	CarcinogensIBA 01/2018 - 01/2015
2	Presenilin-1IBA 01/2015 - 01/2014
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 02/2011 - 12/2009
2	Paclitaxel (Taxol)FDA LinkGeneric 02/2011 - 10/2002
2	vatalanib (PTK787)IBA 02/2011 - 12/2007
2	Activin Receptors (Activin Receptor)IBA 01/2010 - 08/2002
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2009 - 03/2008
2	Platelet-Derived Growth Factor alpha ReceptorIBA 01/2007 - 10/2004
2	LigandsIBA 03/2004 - 08/2002
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2003 - 03/2002
1	DNA Methyltransferase 3AIBA 01/2022
1	Adenosine Triphosphate (ATP)IBA 01/2022
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2022
1	Cadherins (E-Cadherin)IBA 01/2022
1	Red Fluorescent ProteinIBA 01/2022
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 11/2021
1	RNA (Ribonucleic Acid)IBA 11/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 03/2021
1	Cytostatic AgentsIBA 01/2021
1	T0901317IBA 05/2019
1	CalponinsIBA 05/2019
1	Fatty Acid Synthases (Fatty Acid Synthase)IBA 05/2019
1	Liver X ReceptorsIBA 05/2019
1	Fibronectins (Fibronectin)IBA 05/2019
1	ChromatinIBA 01/2019
1	Hyaluronan SynthasesIBA 01/2019
1	Antisense RNA (Anti-Sense RNA)IBA 01/2019
1	Blocking AntibodiesIBA 12/2018
1	Zinc Finger E-box-Binding Homeobox 1IBA 10/2018
1	Karyopherins (Importin)IBA 01/2018

Therapy/Procedure

11	Therapeutics 01/2020 - 10/2004
3	Drug Therapy (Chemotherapy) 02/2011 - 10/2002